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10.1016/j.plaphy.2014.02.010 27 DattaR.KumarD.SultanaA.HazraS.BhattacharyyaD.ChattopadhyayS

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The C-domain is composed of an alpha/beta super-secondary structure, which is common of the Rossmann fold

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The major factor that appears to mediate the COX-2 expression in isolated gastric cancer cells is gastrin, which is also capable of stimulating the expression of growth factors such as hepatocyte growth factor (HGF) and antiapoptotic proteins such as BCL2 ( Fig